12 Bucket List-Worthy Places in South America to Call Home

You know what’s wild? I never expected to fall so hard for South America. But after bouncing around this incredible continent, I get why people aren’t just visiting anymore—they’re actually moving here. And honestly? I totally get it.

I’ll never forget sipping my morning coffee on my apartment balcony in Medellín, watching the sunrise paint those mountains gold, or strolling through Buenos Aires’ Palermo neighborhood feeling like I’d somehow teleported to Paris (but with better steak). These experiences showed me exactly why the best places in South America are drawing in everyone, from remote workers to retirees. Ready to swap your current view for something a bit more exciting? Here are 12 cities where you might just find your next home.

Most Amazing Places to Live in South America     

Looking for the best places to live in South America? Experience the dynamic energy of São Paulo, a hub for business, culture, and nightlife. Enjoy the European charm of Buenos Aires, known for its rich history, tango, and café culture. Settle in Santiago, a city offering stunning mountain views, modern amenities, and a strong economy. Or embrace the vibrant lifestyle of Medellín, famous for its innovation, mild climate, and welcoming community. Whether you seek excitement, culture, or a high quality of life, these are some of the top places to live in South America.

• Best for nightlife: São Paulo
• Best for European charm and arts: Buenos Aires
• Best for historic architecture: Santiago
• Best for innovative urban transformation: Medellin
• Best for colonial heritage: Cuenca
• Best for seaside living: Lima
• Best for outdoor activities: Rio de Janeiro
• Best for cultural richness: Quito
• Best for safety and quality of life: Montevideo
• Best for dynamic city life: Bogota
• Best for beachfront: Rio de Janeiro
• Best for high-altitude living: La Paz

1. Santiago, Chile

Framed by the snow-capped Andes, Santiago is a vibrant mix of history, modernity, and outdoor adventure. As Chile’s capital, it offers a high quality of life, strong infrastructure, and a dynamic cultural scene.

Neighborhoods like Providencia and Las Condes boast tree-lined streets, trendy cafés, and excellent public transport, making them favorites among expats and professionals. Meanwhile, Bellavista is the city’s artistic heart, filled with colorful murals, bohemian bars, and live music venues.

Santiago’s location is a dream for outdoor lovers—just a short drive away, you’ll find world-class ski resorts in the Andes or beautiful vineyards in the Maipo Valley. The city itself has abundant green spaces, including Parque Metropolitano, home to the famous San Cristóbal Hill.

With top-rated universities, excellent healthcare, and a thriving economy, Santiago is a fantastic place for families, students, and professionals looking for an exciting yet livable South American city.

• Read Next: Most Beautiful Places to Visit in Chile

2. Medellin, Colombia

Once known for its turbulent past, Medellín has transformed into one of South America’s most innovative and livable cities. Nicknamed the “City of Eternal Spring” for its year-round mild climate, it offers lush green spaces, modern infrastructure, and a welcoming expat community.

The neighborhoods of El Poblado and Laureles are hotspots for digital nomads and entrepreneurs, featuring trendy cafés, co-working spaces, and a buzzing nightlife scene. The city’s efficient Metro and cable car system makes commuting easy, connecting even the hilltop neighborhoods. Medellín’s culture is thriving, with street art, music, and dance filling the streets of Comuna 13—a once-dangerous area that’s now a symbol of resilience and creativity. For nature lovers, the nearby Andes mountains offer endless opportunities for hiking and adventure sports.

Affordable cost of living, warm community, and rapid growth—Medellín has become a top destination for expats and remote workers looking for safety, innovation, and an active lifestyle.

3. Buenos Aires, Argentina

With its grand boulevards, historic architecture, and passionate culture, Buenos Aires exudes European elegance with a Latin American twist. Known as the “Paris of South America,” Argentina’s capital is a hub for art, literature, and world-class cuisine.

Neighborhoods like Palermo and Recoleta are home to stylish cafés, leafy parks, and boutique shops, while San Telmo captures the city’s bohemian charm with its cobblestone streets and lively tango performances. The city’s love for football and nightlife means there’s always something happening, from live music in bars to packed stadiums on game day.

Buenos Aires is also one of the most affordable major cities in South America, making it a favorite among expats, retirees, and digital nomads. Whether you’re sipping Malbec in a historic café, exploring its many museums, or catching a show at Teatro Colón, Buenos Aires delivers endless culture and excitement.

4. Bogota, Colombia

A city of contrasts, Bogotá blends historic charm with a dynamic modern scene. As Colombia’s capital, it’s a center for business, education, and the arts, attracting a mix of young professionals, creatives, and international expats.

The historic La Candelaria district is the heart of Bogotá’s colonial past, with colorful streets, historic churches, and must-see museums like the Gold Museum. In contrast, the upscale Zona T and Chapinero neighborhoods offer trendy cafés, fine dining, and a thriving nightlife scene.

Outdoor lovers will find plenty to explore, from hiking up Monserrate for breathtaking city views to day trips into the Andes for adventure sports. Bogotá’s mild climate and expanding public transport make it a comfortable and efficient place to live. With a strong job market, rich cultural scene, and a cost of living lower than many global capitals, Bogotá is an exciting and rewarding place to call home.

5. Cusco, Peru

Living in Cusco feels like stepping into history. Once the heart of the Inca Empire, this city is one of the most culturally rich places to live in South America. Cobblestone streets, centuries-old churches, and vibrant markets make every day an experience.

While Cusco is often seen as a gateway to Machu Picchu, it’s also a fantastic place to live for history lovers and adventure seekers. The San Blas neighborhood is a favorite for expats and artists, offering stunning mountain views and a lively arts scene.

Cusco’s cost of living is incredibly affordable, and despite its high altitude, it has a mild climate with plenty of sunny days. The surrounding Sacred Valley offers endless opportunities for hiking, exploring ancient ruins, and immersing yourself in Andean culture.

For those looking for a unique, historic, and nature-filled lifestyle, Cusco is an unforgettable place to visit or live in.

• Read Next: Beautiful Places to Visit in Peru

6. Lima, Peru

Overlooking the Pacific Ocean, Lima offers a blend of modern city life, rich history, and one of the world’s best food scenes. Known as the gastronomic capital of South America, it’s a paradise for food lovers, featuring world-renowned restaurants, fresh ceviche, and vibrant street food.

The coastal Miraflores district is one of the best places to live, offering oceanfront parks, trendy cafés, and easy access to cultural attractions. Barranco, Lima’s artistic hub, is famous for bohemian streets, colorful murals, and live music venues.

Beyond its vibrant city life, Lima provides quick access to both mountains and beaches, making it perfect for surfing, hiking, or weekend getaways to Machu Picchu. The city also boasts a strong economy, reliable healthcare, and a growing expat community, making it a great option for professionals and retirees alike.

For those seeking coastal living, affordability, and cultural vibrancy, Lima is an incredible place to call home.

7. Rio de Janeiro, Brazil

Few cities in the world match the energy and beauty of Rio de Janeiro. Nestled between golden beaches and lush mountains, Brazil’s most famous city is a paradise for outdoor lovers, culture seekers, and beach enthusiasts.

Life in Rio revolves around its stunning coastline, with neighborhoods like Copacabana and Ipanema offering bustling beach scenes, lively cafés, and breathtaking sunsets. For adventure seekers, Tijuca National Park provides hiking trails with panoramic views of the city, while the iconic Christ the Redeemer and Sugarloaf Mountain are must-see landmarks.

Rio is also Brazil’s cultural heart, home to samba, football, and the world-famous Carnival. Despite its fast-paced lifestyle, locals—Cariocas—are known for their relaxed, friendly attitude.

With a warm climate, endless entertainment, and a vibrant social scene, Rio is perfect for those seeking a dynamic, sun-soaked lifestyle in one of South America’s most iconic cities.

8. Quito, Ecuador

Perched high in the Andes Mountains, Quito is a city of breathtaking views, rich history, and an affordable cost of living. Ecuador’s capital offers a unique mix of colonial charm and modern conveniences, making it an attractive place to call home.

Quito’s historic Old Town—a UNESCO World Heritage Site—is filled with cobblestone streets, grand plazas, and centuries-old churches. Meanwhile, neighborhoods like La Floresta and Cumbayá offer a vibrant arts scene, trendy cafés, and a growing expat community.

The city’s year-round spring-like weather is another major draw, as is its proximity to nature—weekend trips to Cotopaxi Volcano, Mindo Cloud Forest, or the Amazon Rainforest are easily accessible.

With affordable living costs, excellent healthcare, and a welcoming community, Quito is an ideal destination for those seeking a high-altitude, culture-rich lifestyle with stunning natural surroundings.

• Read Next: Most Beautiful Places to Visit in Ecuador

9. Montevideo, Uruguay

Uruguay’s capital, Montevideo, is a hidden gem offering an unbeatable mix of safety, culture, and beachfront living. This laid-back city is perfect for those who want a relaxed lifestyle with modern comforts.

Montevideo’s Rambla, a scenic waterfront promenade, stretches for 13 miles along the Rio de la Plata, offering a perfect setting for biking, jogging, or enjoying Uruguay’s famous mate tea. The city’s neighborhoods range from the historic charm of Ciudad Vieja to the more residential and expat-friendly Pocitos.

Unlike many bustling capitals, Montevideo has a slower pace, friendly locals, and a strong sense of community. It’s consistently ranked one of South America’s safest cities, and Uruguay’s progressive policies, excellent healthcare, and strong economy make it an attractive destination for expats.

For those seeking beachside living with a European feel and a high quality of life, Montevideo is a fantastic place to settle down.

10. São Paulo, Brazil

As the economic powerhouse of Brazil, São Paulo is South America’s largest and most dynamic city. A hub for business, arts, and culture, it offers limitless opportunities for professionals and entrepreneurs.

Each neighborhood has its own personality—Jardins is known for luxury shopping and fine dining, while Liberdade is the heart of São Paulo’s Japanese community, offering authentic cuisine and cultural festivals. The city’s art scene is world-class, with institutions like MASP (São Paulo Museum of Art) and the Beco do Batman street art district drawing visitors worldwide.

Food lovers will thrive here—São Paulo has some of the best restaurants in Latin America, serving everything from Brazilian feijoada to Michelin-starred cuisine.

For those looking for a fast-paced, career-driven lifestyle with access to incredible culture, nightlife, and international opportunities, São Paulo is one of the best cities to live in South America.

11. Cuenca, Ecuador

A charming colonial city in Ecuador’s highlands, Cuenca is beloved for its affordable cost of living, stunning architecture, and relaxed pace of life. It’s consistently ranked one of the best places to retire in South America, but it also attracts artists, digital nomads, and history lovers.

Cobblestone streets, historic cathedrals, and colorful markets give Cuenca a storybook feel, while its lively expat community makes it easy to settle in. The city is also a hub for artisan crafts, famous for producing handwoven Panama hats and traditional pottery.

Outdoor enthusiasts will appreciate the proximity to Cajas National Park, offering pristine lakes and hiking trails in the Andes. Cuenca also has excellent healthcare, a mild climate, and reliable public transport, making daily life stress-free.

If you’re seeking affordability, rich culture, and breathtaking scenery, Cuenca is one of South America’s most livable cities.

12. La Paz, Bolivia

Picture this—a city cradled by towering Andean peaks, where cable cars glide above colorful streets, and the air hums with the energy of markets, music, and centuries-old traditions. At 3,650 meters (11,975 feet) above sea level, La Paz is a world of its own.

Stroll through the Witches’ Market, where vendors sell mystical herbs, talismans, and traditional remedies, or wander Calle Jaén, a beautifully preserved colonial street lined with museums and cafés. In Zona Sur, you’ll find modern comforts—boutique shops, craft breweries, and a buzzing restaurant scene.

Exploring beyond the city is just as thrilling—Valle de la Luna’s surreal rock formations and the legendary Death Road biking trail are within easy reach. While adjusting to the altitude takes time, those who stay are rewarded with a city unlike any other—full of adventure, history, and breathtaking scenery.

• Read Next: Beautiful Places in Bolivia

Frequently Asked Questions (FAQs) About the Best Places to Live in South America   

Interested in learning more about top living destinations in South America? Let’s delve into some frequently asked questions about the best places to settle in this vibrant continent.

Which is the best place to live in South America?

The answer to “which is the best place to live in South America” truly depends on what you’re seeking. If you value vibrant culture and a bustling city life, Buenos Aires and São Paulo are top contenders. For those who prefer a blend of urban convenience and natural beauty, Santiago and Rio de Janeiro are excellent choices. For a more relaxed pace with rich historical backgrounds, Cuenca and Quito are ideal. Ultimately, the best place varies based on individual preferences for climate, culture, lifestyle, and amenities.

What is the safest place to live in South America?

When considering safety, Montevideo in Uruguay often ranks as one of the safest places in South America. It’s known for its stable political environment, low crime rates, and a high standard of living. Additionally, cities like Santiago, Chile, and Buenos Aires, Argentina, are also notable for their improved safety measures and expat-friendly environments. It’s important to remember that safety can vary within cities, so researching specific neighborhoods and staying informed about local safety guidelines is crucial.

Where is the most affordable place to live in South America?

In terms of affordability, Cuenca, Ecuador, stands out as one of the most budget-friendly places to live in South America. It offers a low cost of living while providing a high quality of life, including modern amenities and healthcare. Other affordable options include cities like Medellin, Colombia, and La Paz, Bolivia, known for their reasonable living expenses without compromising on culture and lifestyle. These cities provide an excellent balance of affordability and richness in experiences, making them attractive for expats and retirees.

Which city in South America has more job opportunities?

São Paulo, Brazil, is often considered the city with the most job opportunities in South America. As a major business hub, it’s home to numerous multinational companies and industries, offering diverse career options in finance, technology, manufacturing, and more. Buenos Aires, Argentina, and Santiago, Chile, are also known for their robust job markets, particularly in sectors like tech, business, and education. These cities attract professionals from around the world due to their dynamic economies and range of opportunities.

What are the top 3 cities in South America to work?

• São Paulo, Brazil: As the financial heart of Brazil, São Paulo offers extensive opportunities in various sectors, including finance, technology, and commerce. Its dynamic business environment attracts global corporations and startups alike.

• Buenos Aires, Argentina: Known for its European flair, Buenos Aires is a cultural and economic hub with strengths in industries like finance, tech, and creative sectors. The city’s rich cultural scene also makes it an attractive place for expats.

• Santiago, Chile: Santiago’s stable economy and continuous growth make it a top choice for work in South America. Key sectors include mining, finance, and telecommunications. The city’s business-friendly environment and quality of life are additional draws.

These cities offer a blend of robust job markets, diverse career opportunities, and a high quality of life, making them top choices for working in South America.

Final Thoughts on the Best Places to Live in South America

South America, a continent rich in diversity and culture, offers a myriad of choices for those seeking a new place to call home. From the bustling streets of São Paulo to the tranquil beauty of Cuenca, each city presents its unique blend of lifestyle, culture, and opportunities.

For those in pursuit of vibrant city life and economic opportunities, São Paulo, Buenos Aires, and Santiago stand out as top choices. These cities are not just the best cities to live in South America; they are hubs of cultural diversity and economic growth.

On the other hand, if tranquility and affordability are what you seek, cities like Cuenca and Medellin offer a peaceful life without compromising on modern amenities and cultural experiences. They epitomize the good places to live in South America, balancing cost of living with quality of life.

And for the lovers of natural beauty and outdoor adventures, Rio de Janeiro and Quito are unmatched. Their stunning landscapes and vibrant local cultures make them great places to live in South America.

So, what are the best places to move in South America? The answer is as varied as the continent itself. Whether you are drawn to the hustle of big cities, the charm of historic towns, or the tranquility of seaside locales, South America has something to offer for every preference and lifestyle. It’s more than just a place to live; it’s a continent of life, culture, and endless possibilities.