Ready to see the Southwest like never before? 🌄 Think treehouses tucked among red rocks, cozy casitas full of Southwestern charm, and off-grid hideaways where you can unplug and unwind. The Southwest USA is packed with unique places that go way beyond the typical hotel stay, and I’ve handpicked some of the absolute best Airbnbs for your next adventure.
Whether you’re looking to explore the deserts of Arizona, soak up the vibrant culture of New Mexico, or kick back under starlit skies in Utah, this list has something special for every kind of traveler. So if you’re dreaming of a stay that brings you right into the heart of the Southwest’s epic landscapes and one-of-a-kind vibe, here are 9 of the best Airbnbs that’ll make your trip unforgettable!
The Coolest Airbnbs in the Southwest: Top Vacation Rentals in 2025
Here are the best Airbnbs in the Southwestern US by category, taking into account unique amenities, trip types, and budgets. The next sections will cover each listing—and other top vacation rentals— in more detail.
- Top Airbnb in the Southwest: The Ark Tiny House Near Zion National Park
- Best Luxury Rental Southwestern US: Luxury Cabin in Sedona AZ
- Top Romantic Airbnb in the Southwest: Private Lake Cottage near Mesa Verde
- Best Southwest Airbnb for Large Groups: Casa Águila Dorada
- Best Cheap Airbnb in the Southwest: Tiny House near Las Vegas
- Coolest Treehouse Airbnb in the Southwest: Fantasy Treehouse in Utah
- Best Cabin Rental Southwest USA: The Boundary Cabin
- Top Casita Rental in the Southwest: Private Casita with Mountain Views
- Most Unique Airbnb in the American Southwest: Tipi in the Mojave near Las Vegas
14 Best Airbnbs in the Southwest USA
If romantic desert glamping, cabins, and luxury rentals all sound good to you, you’re in for a treat! Here are some of the most unique stays in the American Southwest.
Note: Some of the properties below are featured on both Airbnb and VRBO. For each listing, I’ve only included the link to the website with the cheapest rates.
1. Tiny House near Las Vegas
Location: Sandy Valley, Nevada
Rates from: $113 per night
Accommodates: 3 guests
Experience the southwest US in style from this modern tiny house rental in Nevada. This desert hideaway lies on a ranch with horseback riding, cattle drives, and rodeo events.
Take in the unobstructed views of the Mojave Desert and gaze up at a sea of stars. There are several amazing attractions nearby, including Death Valley, Tecopa Hot Springs, and GoodSprings. However, after stepping foot inside this beautiful southwest vacation rental, you won’t want to leave!
2. Modern A-Frame with Majestic Sunset Views
Location: Pine, AZ, Southwest US
Rates from: $179 per night
Accommodates: 5 guests
Tucked away in the serene landscapes of Pine, Arizona, the Modern A-Frame with Majestic Sunset Views offers a unique blend of modern architecture and nature’s tranquility. With a stellar rating of 5.0 out of 5, this property promises an experience that is both luxurious and unforgettable.
The A-Frame features two elegantly designed bedrooms. The primary bedroom is furnished with a plush queen bed, ensuring a restful night’s sleep amidst the calming surroundings. The secondary bedroom provides a combination of a twin bed and a queen bed, catering to a variety of guest preferences. The property also boasts two well-appointed bathrooms, ensuring convenience and comfort for all guests.
One of the standout features of this property is its expansive deck, which offers guests a mesmerizing view that captures the essence of nature’s beauty without the need for any filters or edits. Essential amenities such as a fully-equipped kitchen, washer, dryer, free WiFi, and air conditioning ensure that guests have a seamless and comfortable stay.
Situated in Pine, AZ, this Modern A-Frame‘s prime location provides guests with the opportunity to explore nearby attractions. Art enthusiasts can take a short drive to Myra’s Art Gallery, and for those traveling by air, the Payson, AZ (PJB) airport is conveniently located just 27 minutes away.
3. Executive Home in Soledad Canyon – One of the Coolest Airbnb Rentals in the Southwest USA
Location: Las Cruces, New Mexico
Rates from: $390 per night
Accommodates: 13 guests
This Airbnb in New Mexico is nothing short of a desert oasis. It stands tall above Soledad Canyon with epic views of the surrounding landscape.
Wake up every morning with a cup of coffee or tea as you watch the wildlife moving throughout the canyon. Take advantage of the modern amenities inside this luxurious home. Explore nearby Organ Mountains National Monument, and other regional attractions that you won’t find anywhere else in the country. Is this one of the best Airbnbs in the southwest? It sure is!
4. Zion’s Cable Mountain Trail Head Cabin
Location: Orderville, UT, Southwest US
Rates from: $250 per night
Accommodates: 6 guests
Tucked away in the scenic landscapes of Orderville, Utah, Zion’s Cable Mountain Trail Head Cabin offers a serene retreat for nature enthusiasts. With an outstanding rating of 4.9 out of 5, guests are guaranteed a stay that is both comfortable and memorable.
The cabin features a bedroom equipped with two twin beds, ensuring a restful night’s sleep for its guests. The property also includes a bathroom, equipped with essentials such as a bathtub, shower, and toilet. One of the standout features of this cabin is its proximity to the majestic East Zion National Park, making it a perfect base for those looking to explore the natural wonders of the region.
Guests can relax on the deck or patio, taking in the beauty of the surroundings. The cabin also offers amenities such as a kitchen, free WiFi, air conditioning, and an outdoor space. Additionally, the cabin boasts a unique pizza oven, perfect for roasting marshmallows and enjoying a cozy evening by the fire.
Situated in Orderville, UT, the cabin‘s prime location provides easy access to local attractions. A short 4-minute drive will take guests to the Clear Creek Overlook, and the iconic Zion National Park is just a 19-minute drive away. These are some of the top things to do in the American Southwest. For those traveling by air, the Kanab, UT (KNB) airport is conveniently located just 58 minutes away.
5. Tipi in the Mojave Desert
Location: Sandy Valley, Nevada
Rates from: $115 per night
Accommodates: 3 guests
Ever dreamed of sleeping in a tipi? This authentic vacation rental in the southwest has got you covered.
This tipi has all the comforts of home in an idyllic desert setting. Enjoy an outdoor shower with hot water and breathtaking views. Watch horse rides, cattle drives, rodeos, and cowboy games that take place on the property. Discover some solitude hiking around the expansive desert terrain. With so much charm and personality, it’s no wonder this tipi rental is among the most unique places to visit in the American Southwest.
6. Lakefront Lux Seclusion on St. Mary’s
Location: Idaho Springs, CO
Rates from: $899 per night
Accommodates: 6 guests
Discover serene mountain luxury at this lakefront cabin on pristine St. Mary’s Lake in Idaho Springs, CO. Perfect for families or couples, this spacious 1,787 sq. ft. retreat boasts three bedrooms, two bathrooms, and panoramic views of the surrounding mountains, lake, and lush forests. The stylish living room offers plenty of seating and epic views from every angle, and outdoor spaces include a balcony, deck, and garden to fully enjoy Colorado’s beauty. Located minutes from Saint Mary’s Glacier and nearby trails, this pet-friendly cabin combines seclusion with easy access to outdoor adventures, making it an ideal spot for relaxation and exploration.
7. The Ark Tiny House near Zion National Park
Location: Virgin, Utah
Rates from: $360 per night
Accommodates: 6 guests
This tiny house rental in the Southwest is one of the most beautiful Airbnb imaginable. It’s nestled on a 75-acre property within reach of Zion National Park, but it’s easy to forget that when you’re standing inside this beautiful home.
Watch sunrises and sunsets from the gorgeous bay windows throughout the home. Snuggle up in the cozy loft. Soak in the hot tub and make s’mores on the firepit. This Southwest Airbnb is truly the ultimate Zion getaway. After spending a weekend here, you won’t want to visit anywhere else!
8. The Boundary Cabin 7 – One of the Best-Value Airbnbs in the American Southwest
Location: Kane County, Utah
Rates from: $150 per night
Accommodates: 2 guests
Looking for a secluded cabin getaway in the southwest? Look no further than this rustic accommodation in Utah.
This luxurious rental embodies the best that the Southwest has to offer, including epic views, a fire pit, and other rustic amenities and fixtures. You’ll only be one mile away from the entrance of Zion National Park. What more could you want in a top Airbnb in the Southwest?
9. Luxury Grand Estate with Pool & Casita
Location: Santa Fe, NM, Southwest US
Rates from: $1,671 per night
Accommodates: 12 guests
Nestled in the enchanting landscapes of Santa Fe, New Mexico, the Luxury Grand Estate with Pool & Casita stands as a testament to opulence and comfort. With an impeccable rating of 5.0 out of 5, guests are assured of a stay that is both luxurious and unforgettable.
The estate boasts six meticulously designed bedrooms. The assortment includes rooms with king beds and queen beds, ensuring a restful night’s sleep for its guests. The property is equipped with eight bathrooms, ensuring convenience and comfort for all guests.
One of the standout features of this estate is its majestic pool, offering guests a refreshing escape amidst the serene surroundings. The inclusion of a casita adds to the charm of this property, providing an additional space for relaxation. Essential amenities such as a kitchen, washer, dryer, air conditioning, and an outdoor space ensure that guests have a seamless and comfortable stay.
Situated in Santa Fe, NM, the estate‘s prime location provides easy access to local attractions. A short 6-minute drive will take guests to the historic Santa Fe Plaza, the iconic Loretto Chapel is just a 7-minute drive away, and the serene Santa Fe National Cemetery is a mere 9-minute drive.
10. Luxury Cabin with Red Rock Views – Among the Top Luxury Airbnbs in the Southwest US
Location: Sedona, Arizona
Rates from: $1,899 per night
Accommodates: 14 guests
Enjoy peace and tranquility from this 5-bedroom luxury cabin rental in Arizona. It’s just minutes away from shops and restaurants, but it feels worlds away as you’re traversing the private creeks, swimming holes, and other unique landscapes on the property.
Spend your days hiking around Sedona, and once night rolls around, relax in the hot tub beneath a sky full of stars. With amazing amenities and panoramic views, this is easily one of the best Airbnb rentals in the Southwest.
11. Private Lake Cottage near Mesa Verde Entrance
Location: Mancos, Colorado
Rates from: $259 per night
Accommodates: 4 guests
This private lake cottage in Colorado exudes beauty and personality. It lies on 60 acres of nature preserve land with its own private lake.
This secluded vacation rental is just 10 minutes away from Mesa Verde and 7 minutes from downtown Mancos. Explore the national park and all its archaeological sites and natural wonder. Go canoeing and fishing in the private lake just steps from the house, and don’t forget to enjoy some R&R from the hot tub with lake views. Is this one of the most romantic Southwest Airbnbs? Absolutely!
Read next: Most Unique Colorado Rentals
12. Fantasy Treehouse Resort in Utah – A Top Airbnb in the Southwest for Nature Lovers
Location: Nephi, Utah
Rates from: $140 per night
Accommodates: 6 guests
At this treehouse rental in Utah, you’ll feel like you’ve entered into another world. This whimsical accommodation floats in the trees, connected to the ground by a 70 ft. suspension bridge.
From the moment you step foot inside this southwest vacation rental, prepare to be amazed by the rustic cabin vibes, spacious deck, and other cool amenities. Relax in the spa with views of trees. Enjoy a barbecue and take advantage of the gas fire pit. This treehouse rental is truly the perfect place to visit every time of year.
13. Rustic Romantic Treehouse Near Cloudcroft New Mexico
Location: Mayhill, NM, Southwest US
Rates from: $169 per night
Accommodates: 4 guests
Nestled in the serene landscapes of Mayhill, New Mexico, the Rustic Romantic Treehouse offers a unique and enchanting escape for those seeking a blend of nature and romance. With its rustic charm and cozy ambiance, guests are guaranteed a stay that is both tranquil and memorable.
The treehouse features a main room equipped with a comfortable queen bed, ensuring a restful night’s sleep amidst the treetops. The property also boasts a bathroom equipped with essentials such as soap, towels, shampoo, and a hair dryer. One of the standout features of this treehouse is its balcony, offering guests a bird’s-eye view of the surrounding nature.
Guests can enjoy the amenities such as a kitchenette, air conditioning, barbecue grill, and a fireplace, ensuring a cozy and comfortable stay. The mountain view from the property adds to its charm, making it a perfect spot for relaxation and rejuvenation.
Situated in Mayhill, NM, the treehouse’s prime location provides easy access to local attractions. A short 17-minute drive will take guests to the Cloudcroft Ski Area, the Trestle Recreation Area is just a 22-minute drive away, and the New Mexico Rails-to-Trails is a mere 23-minute drive. This area is one of the most livable places in the American Southwest.
14. Mountain View Private Casita Airbnb in the Southwest US
Location: Mesa, Arizona
Rates from: $130 per night
Accommodates: 2 guests
This budget-friendly casita in Arizona offers the perfect dose of serenity that you’ll need on a southwest US road trip. It’s located on a 1-acre lot in the desert within 2 miles of Tonto National Forest and Saguaro Lake.
Wake up every morning to breathtaking views of the desert and surrounding mountains. Go swimming in the pool and soak up the sun from the lounge chairs. Have a nice southwestern barbecue in the backyard as you reflect on your amazing trip to the southwest. After spending a weekend or longer at this gorgeous and authentic Arizona Airbnb, you’ll definitely want to come back for more.
Coolest Airbnbs for Rent in the Southwest: Arizona, Colorado, Nevada, New Mexico, and Utah
Have you ever stayed in a unique Airbnb or vacation rental in the Southwest region of the US? Let me know in the comments or on Instagram, as I’m always excited to add to this list of the best Airbnbs in the Southwestern USA!
Looking for more outdoor adventure destinations? Check out these places:
– Coolest Rentals in the Midwest
– Most Unique Airbnbs in Jackson Hole
– Best Airbnbs Across Colorado
– Coolest Stays in Western Massachusetts
– Top Airbnb Rentals in the White Mountains
– The Most Unique Stays in New England
